Investigating the Benefits of Remotely Supervised Neuromodulation in Primary Progressive Aphasia
NIH/NIA RF1AG085565 | 2025–2029 | PIs: Henry & Richardson; Co-I: Grasso | NCT07260253

Primary progressive aphasia (PPA) is an Alzheimer's-related condition in which language abilities decline while other cognitive functions remain relatively intact. This randomized controlled trial examines whether pairing remotely delivered brain stimulation (neuromodulation) with speech-language treatment produces better communication outcomes than treatment alone. A secondary aim is to identify neural markers that predict who is most likely to benefit, a step toward truly personalized care. This study represents one of the first large-scale trials of home-based neuromodulation in PPA and has the potential to reshape how we think about treatment delivery for this population.

Intervention to Promote Communication and Quality of Life for Persons with Language-Led Dementia and Their Partners
NIH/NIA R61AG089318 | 2025–2027 | PIs: Henry & Grasso | NCT07219680

Communication loss is one of the most distressing features of dementia, yet speech-language services remain difficult to access for many families. This randomized pilot and feasibility trial tests the Multi-PA telerehabilitation protocol, a telehealth-delivered program that combines personalized speech-language treatment with training in compensatory communication strategies for both the person with dementia and their care partner. By treating the dyad together and delivering services remotely, Multi-PA is designed to reach families regardless of geography and to support quality of life across the course of the disease. This study is open to individuals with language-prominent forms of dementia and their communication partners.